Síntesis de nitroderivados de hidroxitirosol como potenciales inhibidores de COMT. Article in Basic & Clinical Pharmacology & Toxicology · January . The principle aim of COMT inhibitor therapy is to increase the duration of El principal objetivo del tratamiento con inhibidores de la COMT es. AMPT: α-metil-p-tirosina; COMT: catecol-O- . gena en la circulación, primero son metiladas por la COMT y con- Existen también inhibidores de la COMT.

Author: Vijin Micage
Country: Moldova, Republic of
Language: English (Spanish)
Genre: Science
Published (Last): 2 April 2011
Pages: 389
PDF File Size: 15.79 Mb
ePub File Size: 2.67 Mb
ISBN: 887-5-13012-182-6
Downloads: 23989
Price: Free* [*Free Regsitration Required]
Uploader: Vuran

The enzyme introduces a methyl group to the catecholamine, which is donated by S-adenosyl methionine SAM. Tryptophan hydroxylase Aromatic L-amino acid decarboxylase Aralkylamine N-acetyltransferase Acetylserotonin O-methyltransferase.

Molecular and Cellular Biology portal. Levodopaa precursor of catecholamines, is an important substrate of COMT. The British Journal of Psychiatry. Student consult 7th ed.

EST3 – Inhibidores de la comt. – Google Patents

Journal of Neural Transmission. Journal of Alzheimer’s Disease. This article relies too much on references to primary sources.

This page was last edited on 21 Novemberat The gene is associated with allelic variants. When given with an inhibitor of dopa decarboxylase carbidopa or benserazidelevodopa is optimally saved.

However, there seems to be a trend for tolcapone to induce more often diarrhoea and increase in liver transaminases compared with entacapone. Both pharmacokinetically and clinically the mg dose of entacapone is the most effective dose compared with placebo.


By using this site, you agree to the Terms of Use and Privacy Policy.

The Journal of Biological Chemistry. Any compound dee a catechol structure, like catecholestrogens and catechol-containing flavonoids, are substrates of COMT.

Neurotransmitters and their receptors”. EC number Enzyme superfamily Enzyme family List of enzymes. Retrieved November 16, Lay summary — MedWireNews.

ES2282924T3 – Inhibidores de la comt. – Google Patents

The O in the name stands for oxygennot for ortho. They induce a dose-dependent inhibition of COMT activity in erythrocytes and a significant decrease in the plasma levels of 3-O-methyldopa, indicating their effectiveness as COMT inhibitors.

A functional single-nucleotide polymorphism a common normal variant of the gene for catechol-O-methyltransferase results in a valine to methionine mutation at position Val L rs Oroszi G, Goldman D December The American Journal of Psychiatry. However, tolcapone is clinically restricted owning to its increased hepatotoxicity and other related digestive disorders.

December Learn how and when to remove this template message. COMT inhibitors include tolcaponeentacapone and opicaponewhich are used in the treatment of Parkinson’s disease. The gene variant has been shown to affect cognitive tasks broadly related to executive functionsuch as set shifting, response inhibition, abstract thought, and the acquisition of rules or task structure.


Views Read Edit View history. In the brain, COMT-dependent dopamine degradation is of particular importance in brain regions with low expression of the presynaptic dopamine transporter DATsuch as the prefrontal cortex. Serine hydroxymethyltransferase 3-methyloxobutanoate hydroxymethyltransferase.

Histamine N-methyltransferase Phenylethanolamine N-methyltransferase Amine N-methyltransferase Phosphatidylethanolamine N-methyltransferase.

COMT inhibition in the treatment of Parkinson’s disease.

Research conducted at the Section ocmt Neurobiology of PsychosisInstitute of Psychiatry, King’s College London has demonstrated an effect of COMT both in patients with bipolar disorder and in their relatives, [36] [ unreliable medical source ] but these findings have not been replicated so far. More reference expression data. Chromosome 22 human [1]. Genes on human chromosome 22 EC 2.

Histamine N-methyltransferase Diamine oxidase. Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator. Goetz CG May Cholinesterase AcetylcholinesteraseButyrylcholinesterase. The effect size of genotypic moderation was quite large: American Journal of Human Genetics. Aspartate carbamoyltransferase Ornithine carbamoyltransferase Oxamate carbamoyltransferase Putrescine carbamoyltransferase ibhibidores carbamoyltransferase Lysine carbamoyltransferase N-acetylornithine carbamoyltransferase.