Primary infection with HHV-6 may be asymptomatic, or it may cause the exanthem subitum/roseola syndrome. Within that complex, otitis. Roseola infantum is also known as exanthema subitum or sixth disease according to the childhood exanthem classification after measles, scarlet fever, rubella. Exanthema subitum (roseola infantum) is one of the mildest exanthematous diseases to which infants under 2 years are subject. It possesses, however.

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Most cases of HHV-6 infection get better on their own. Fjerde barnesykdom Norwegian [9]. A pale halo can occur around the macules and papules in some cases.

There is no specific treatment for roseola infantum. Viral cutaneous conditions, including viral exanthema B00—B09— Our website uses cookies to enhance your experience. During the fever, children may appear to be active and well. Rubella virus Rubella Congenital rubella syndrome “German measles” Alphavirus infection Chikungunya fever.

Children with cancer and recipients of transplants are at increased risk of reactivation. Purchase access Subscribe to JN Learning for one year.

Reactivation of the virus can occur in immunosuppressed patients. Get free access to newly published articles. The rash is typically nonpruritic, blanching and can persist from one to two days. There is no specific vaccine against or treatment for exanthema subitum, and most children with the disease subitumm not seriously ill. Symptoms usually last days.


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The primary variant that causes roseola infantum is HHV-6B. Pathophysiology Human herpesvirus 6 replicates most commonly in the leukocytes and the salivary glands during the primary infection eksantem will, therefore, be present in saliva. Sign in to make a comment Sign in to your personal account. Create a free personal account to download free article PDFs, sign up for alerts, customize your interests, and more. Numbered Diseases of Childhood.


Blood testing is available for both virus and antibody detection. Questions To access free multiple choice questions on this topic, click here.

Human herpesvirus 6 has two variants: Fever followed by rash [1]. At this time there is no specific treatment. Get free access to newly published articles Create a personal account or sign in to: Purchase access Subscribe to the journal.

Roseola Infantum (Exanthema Subitum, Sixth Disease) – StatPearls – NCBI Bookshelf

Similar articles in PubMed. To access free multiple choice questions on this topic, click here. Review The spectrum of human herpesvirus 6 infection: What is the treatment? Sign in to access your subscriptions Sign in to your personal account. Views Read Edit View history.



Exanthema subitum roseola infantum is one of the mildest exanthematous diseases to which infants under 2 years are subject. Before the age of three [1]. Laboratory and clinical aspects of human herpesvirus 6 infections.

In a JAMA article published on Oct 18, he noted that “the name ‘Roseola infantilis’ had an important place in the medical terminology of writers on skin diseases” but that descriptions of the disease by previous writers tended to confuse it with many other diseases that produce febrile rashes. Create a free personal account to make a comment, download free article PDFs, sign up for alerts and more.

In most cases, the disease is diagnosed based on the appearance of the fever followed by a rash as described above. This section needs additional citations for verification. Lautenschlager I, Loginov R.

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However, children may also have malaise, conjunctivitis, orbital edema, inflammation of the tympanic membranes, lymphadenopathy, irritability, anorexia, a bulging fontanelle, diarrhea, cough and other upper respiratory tract symptoms.

The fever typically lasts three to five days.