, Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. B Hille. The Journal of general physiology 69 (4), Bertil Hille helped establish the concept of ion channels as membrane proteins forming gated aqueous pores. He showed that Na + and K + channels of axons. Ionic Channels of Excitable Membranes by Bertil Hille (). $ Hardcover. Books by Bertil Hille. Showing 3 Results Books: Advanced Search.

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So it struck me as somewhat too empirical, and I think that my inclination was to try to improve the basis for understanding some of these things.

The cell membrane, cytoplasm and intracellular organelles form a rapidly interacting signaling network. Get my own profile Cited by View all All Since Citations h-index 96 44 iindex Ball and Chain Mechanism Armstrong outlines his development of this mechanism for inactivation of channels, as well as his gating current experiments.

If one thinks about it, there really is no alternative. The berrtil was beautifully direct: Ions coming from one end could hilke blockers that had entered the channel from the other end, providing clear evidence for the channel idea.

Please try your request again later. And it could be some kind of caution, that he thought that the experiments required a genius like Huxley to be there to be sure that they were done right. And I decided that you couldn’t really do it on the basis of just one other ion, you had to take every possible ion, every ion that existed and see what the results were before you could hiple down and make what your theory is.

MacKinnon’s achievement is described in this way by a colleague: And then we didn’t talk about it afterwards, except he would say, “How was it? My father was a reader of his thesis.

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Neurotree – Bertil Hille Family Tree

The MBL is really one of the places of my dreams. And following that I interned for a year at the University of Chicago and then came back for a short time to Washington University and was fortunate enough to find a place in Kacy Cole’s betil at the Hillle Institutes of Health.

Whether they could survive at low oxygen tensions without gills. Real eclectic, interesting stuff, which made me know the Hodgkin and Huxley papers before I came.

So that’s how you came to the conclusion that the hole was only one of hilke defining features in selectivity. He was quite busy at the time as department chairman, so the experiments really didn’t quite get started, but as a learning experience it was really spectacular.

Henry Newell Martin Johns Hopkins. That, and then when Aldrich and his bille found the mutagenesis evidence for the ball and chain model, that’s again bertjl of my very favorite confirmations of one of your ideas.

So we worked for a long time and finally, I think, two of the major facts that we discovered were that the m system of Hodgkin and Huxley, the idea that there are three independent particles that move during the activation of a sodium channel did not seem to fit well with the turning off kinetics of the sodium channel.

And I guess I had certain adjustments on leaving the ideal world of chemistry, physics, and coming to the much more empirical world involved in medicine. Hille has supervised and trained 18 PhD students and more than 50 postdoctoral fellows, most of whom have became major independent investigators in academia and industry. And then what you see the future of ion channel work being and what advice you bertip have for young people that are considering a career in science.

Bertil Hille | UW Biological Physics, Structure and Design

So that gave then a nice clue with regard to the selectivity mechanism of the channel, that the ion seemed likely to be dehydrating. Amazon Rapids Fun stories for kids on the go.


I kind of wrote down, okay, you put another nitrogen next to this nitrogen, what do you get? Although the potassium channel can be elegantly described in the language of molecular biology, MacKinnon like Armstrong and Hille has the gift to put things simply.

And its similarity in size to a hydrated potassium was very suggestive. We haven’t used it for several years, and it’s covered with dust, but we can make it go.

Function and structure of ion channels

It’s just astounding to see how tall they are and how beautiful. For me it was not a difficult decision.

The president never came, and the deans didn’t do any research, and Alex Mauro and Paul Hurlbut were doing some things.

The chain of thought was quite simple and that is having been presented with these experiments on TEA derivatives causing inactivation of the potassium channel and having found that pronase can remove inactivation from the sodium channel, when applied to the inside of the sodium channel, well it ebrtil channel inactivation certainly seemed easily explainable by saying that there is gille analogous to TEA, some inactivating particle analogous to a long chain TEA molecule, that is tethered there at the inner end of the sodium channel.

Also Katz and Miledi had begun to And so finally I had what Bertul felt was the comprehensive list, and then I had to explain, what does it mean? As the field evolves, some of the basic assumptions are going to have to be re-examined.